Article

Ontology-aware DNA methylation classification with a curated atlas of human tissues and cell types

2025-04-24

Abstract excerpt

<h4> A bstract </h4> DNA methylation (DNAm) is a core gene regulatory mechanism that captures cellular responses to short- and long-term stimuli such as environmental exposures, aging, and cellular differentiation. Although DNAm has proven valuable as a baseline biomarker for aging by enabling robust characterization of disease-associated methylation shifts associated with age, its potential to reveal analogous...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 907e5a98-5612-510c-9db7-021fff8599fa
DOI: 10.1101/2025.04.18.649618

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ontology-aware DNA methylation classification with a curated atlas of human tissues and cell typesDOI 10.1101/2025.04.18.649618Read

MethylGPT: a foundation model for the DNA methylomeSemantic proximity Read

CpGPT: a Foundation Model for DNA MethylationSemantic proximity Read

A robust computational framework for methylation age and disease-risk prediction based on pairwise learning.Semantic proximity Read

Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.Semantic proximity Read

Local SNP-explained methylation variation reveals genetically anchored and exposure-associated methylation architecture in the human brainSemantic proximity Read

Human whole-epigenome modelling for clinical applications with PleiadesSemantic proximity Read

Human body epigenome maps reveal noncanonical DNA methylation variation.Semantic proximity Read

Deep5hmC: Predicting genome-wide 5-Hydroxymethylcytosine landscape via a multimodal deep learning modelSemantic proximity Read

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.Semantic proximity Read

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Network, Inspired by Capsule NetworksSemantic proximity Read

Melody: Decoding the Sequence Determinants of Locus Specific DNA Methylation Across Human TissuesSemantic proximity Read

Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns.Semantic proximity Read