Article
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns.
Human molecular genetics - 15 Dec 2009
Byun Hyang-Min, Siegmund Kimberly D, Pan Fei, Weisenberger Daniel J, Kanel Gary, Laird Peter W, Yang Allen S
Abstract excerpt
DNA methylation is known to be associated with cell differentiation, aging, disease and cancer. There exists an expanding base of knowledge regarding tissue-specific DNA methylation, but we have little information about person-specific DNA methylation. Here, we analyze the DNA methylation patterns of multiple tissues from multiple individuals using a high-throughput quantitative assay of genome-wide DNA...
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