Article
Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation.
American journal of human genetics - 5 May 2016
Do Catherine, Lang Charles F, Lin John, Darbary Huferesh, Krupska Izabela, Gaba Aulona, Petukhova Lynn, Vonsattel Jean-Paul, Gallagher Mary P, Goland Robin S, Clynes Raphael A, Dwork Andrew, Kral John G, Monk Catherine, Christiano Angela M, Tycko Benjamin
Abstract excerpt
Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in disease-relevant tissues remain sparse. Here we apply array-based and Methyl-Seq approaches to multiple human tissues and cell types, including brain, purified neurons and glia, T lymphocytes, and placenta, and identify 795 hap-ASM differentially methylated regions...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.