Article
MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.
NPJ systems biology and applications - 20 Aug 2021
Levy Joshua J, Chen Youdinghuan, Azizgolshani Nasim, Petersen Curtis L, Titus Alexander J, Moen Erika L, Vaickus Louis J, Salas Lucas A, Christensen Brock C
Abstract excerpt
DNA methylation (DNAm) alterations have been heavily implicated in carcinogenesis and the pathophysiology of diseases through upstream regulation of gene expression. DNAm deep-learning approaches are able to capture features associated with aging, cell type, and disease progression, but lack incorporation of prior biological knowledge. Here, we present modular, user-friendly deep-learning methodology and...
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