Article

High-dose DFMO alters protein translation in neuroblastoma

2025-01-26

Abstract excerpt

<h4>ABSTRACT</h4> DFMO has been studied as a cancer therapeutic at doses ranging from 500-9,000 mg/m2/day. Lower doses are favored for cancer prevention studies while higher doses, often with chemotherapy, are studied in refractory cancers. DFMO inhibits the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase (ODC), an oncogene transcriptionally regulated by MYC. MYC genes are the principal onco...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 907557af-f31f-58b8-b2f3-f586ca7b9a60
DOI: 10.1101/2025.01.23.634327

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-dose DFMO alters protein translation in neuroblastomaDOI 10.1101/2025.01.23.634327Read

High-dose DFMO alters protein translation in neuroblastomaSemantic proximity Read

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and ProgressionSemantic proximity Read

Reprogramming neuroblastoma by diet-enhanced polyamine depletionSemantic proximity Read

Disrupting Polyamine Homeostasis as a Therapeutic Strategy for NeuroblastomaSemantic proximity Read

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastomaSemantic proximity Read

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patientsSemantic proximity Read

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastomaSemantic proximity Read

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma.Semantic proximity Read

Targeting polyamine metabolism for cancer therapy and preventionSemantic proximity Read

Inhibiting mitochondrial translation overcomes multidrug resistance in MYC-driven neuroblastoma via OMA1-mediated integrated stress responseSemantic proximity Read

METTL1 promotes Neuroblastoma development through m 7 G tRNA modification and selective oncogenic gene translationSemantic proximity Read

Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastomaSemantic proximity Read