METTL1 promotes Neuroblastoma development through m 7 G tRNA modification and selective oncogenic gene translation

Abstract excerpt

<h4>Background: </h4> Neuroblastoma (NBL) is a common but aggressive malignancy with a poor prognosis in childhood. Despite existing therapy approaches, the 5-year survival rate for patients with advanced NBL remains below 30%, emphasizing urgent necessary for novel therapeutic strategies. Studies have shown that epigenetic disorders play an essential role in the pathogenesis of NBL. However, the function and mech...

Topics

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• ATP Synthase and ATPases Research
• Autophagy in Disease and Therapy
• Cancer-related gene regulation
• Cardiac Structural Anomalies and Repair
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA modifications and cancer
• Viral-associated cancers and disorders

Identifiers and source

Literature Corpus work

d7060534-d4a5-5d91-bfc0-41079c3096d3

DOI

10.21203/rs.3.rs-1546187/v1