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Article

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

1 Jan 2012

Abstract excerpt

Polyamines are highly regulated essential cations that are elevated in rapidly proliferating tissues, including diverse cancers. Expression analyses in neuroblastomas suggest that up-regulation of polyamine pro-synthetic enzymes and down-regulation of catabolic enzymes is associated with poor prognosis. Polyamine sufficiency may be required for MYCN oncogenicity in MYCN amplified neuroblastoma, and targeting...

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Identifiers

PMID: 23181218
DOI: 10.3389/fonc.2012.00162

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