Article
A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma.
PloS one - 1 Jan 2015
Saulnier Sholler Giselle L, Gerner Eugene W, Bergendahl Genevieve, MacArthur Robert B, VanderWerff Alyssa, Ashikaga Takamaru, Bond Jeffrey P, Ferguson William, Roberts William, Wada Randal K, Eslin Don, Kraveka Jacqueline M, Kaplan Joel, Mitchell Deanna, Parikh Nehal S, Neville Kathleen, Sender Leonard, Higgins Timothy, Kawakita Masao, Hiramatsu Kyoko, Moriya Shun-Suke, Bachmann André S
Abstract excerpt
BACKGROUND: Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extracranial solid tumors in children. Ornithine decarboxylase (ODC) expression is an independent indicator of poor prognosis in NB patients. This study investigated safety, response, pharmacokinetics, genetic and metabolic factors associated with ODC in a clinical trial of the ODC inhibitor...
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