Article

Inhibiting mitochondrial translation overcomes multidrug resistance in MYC-driven neuroblastoma via OMA1-mediated integrated stress response

2023-02-24

Abstract excerpt

<h4>ABSTRACT</h4> High-risk neuroblastoma remains a clinically challenging childhood tumor with a 5-year survival of only 50%. Tumors overexpressing N-MYC or c-MYC oncoproteins define a group of MYC-driven high-risk neuroblastoma with the most dismal outcomes, mainly caused by treatment failure due to the emergence and regrowth of multidrug-resistant cancer cells. Specific mitochondrial processes have been implic...

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Literature Corpus work: 393e4878-ea57-5373-a00c-51688881ff09
DOI: 10.1101/2023.02.24.529852

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