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Article

High-dose DFMO alters protein translation in neuroblastoma

6 Aug 2025

Abstract excerpt

DFMO has been studied as a cancer therapeutic at doses ranging from 500 to 9,000 mg/m2/day. Lower doses are favored for cancer prevention studies while higher doses, often with chemotherapy, are studied in refractory cancers. DFMO inhibits the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase (ODC), an oncogene transcriptionally regulated by MYC. MYC genes are the principal oncogenic drivers of...

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PMID: 40774224
DOI: 10.1016/j.neo.2025.101215

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