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Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma

12 Dec 2018

Abstract excerpt

Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous system, is...

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PMID: 30542116
DOI: 10.1038/s41388-018-0611-7

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