Article

Genome-wide association analysis of age-at-onset traits using Cox mixed-effects models

2019-08-08

Abstract excerpt

Age-at-onset is one of the critical phenotypes in cohort studies of age-related diseases. Large-scale genome-wide association studies (GWAS) of age-at-onset can provide more insights into genetic effects on disease progression, and transitions between different stages. Moreover, proportional hazards or Cox regression generally achieves higher statistical power in a cohort study than a binary trait using logistic r...

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Literature Corpus work: 906b8a13-87ea-596a-a85e-feef71cc643c
DOI: 10.1101/729285

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