Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-ancestry meta-analysis identifies genetic modifiers of age-at-onset of Alzheimer's disease at known and novel loci.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025

Blue Elizabeth E, Broome Jai, Xue Diane, Kingston Hanley, Chapman Nicola H, Gogarten Stephanie, Naj Adam C, Wijsman Ellen M

Abstract excerpt

INTRODUCTION: Much of Alzheimer's disease (AD) risk is explained by age, apolipoprotein E (APOE) genotype, and sex. We sought to identify genetic modifiers of age at onset (AAO) of AD while probing the influence of sex and APOE among those with diverse ancestry. METHODS: We performed genome-wide association studies (GWASs) of AAO in two diverse samples followed by meta-analysis, contrasting results with and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Apolipoproteins E

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Genotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40883957
DOI: 10.1002/alz.70489
PMCID: PMC12397202

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-ancestry meta-analysis identifies genetic modifiers of age-at-onset of Alzheimer's disease at known and novel loci.PMID 40883957Read ↗

A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populationsSemantic proximity Read ↗

Multi-ancestry meta-analysis and fine-mapping in Alzheimer’s DiseaseSemantic proximity Read ↗

Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.Semantic proximity Read ↗

Identifying Individuals at High Risk for Alzheimer’s Disease Among Hispanics Using Single and Multi-Ancestry Polygenic Risk ScoresSemantic proximity Read ↗

Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.Semantic proximity Read ↗

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer’s Disease Risk Prediction in Multiethnic CohortsSemantic proximity Read ↗

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease riskSemantic proximity Read ↗

A Genome-wide Association Study of Alzheimer’s Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated LociSemantic proximity Read ↗

Multi-ancestry studies in multi-omics of Alzheimer's disease: Recent insights and future directions.Semantic proximity Read ↗

Genomic analyses reveal new insights into Alzheimer's diseaseSemantic proximity Read ↗

The Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodology.Semantic proximity Read ↗

Identification of novel genes for age-at-onset of Alzheimer's disease by combining quantitative and survival trait analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.