Article
A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.
Genetics - 1 May 2018
Wang Xulong, Philip Vivek M, Ananda Guruprasad, White Charles C, Malhotra Ankit, Michalski Paul J, Karuturi Krishna R Murthy, Chintalapudi Sumana R, Acklin Casey, Sasner Michael, Bennett David A, De Jager Philip L, Howell Gareth R, Carter Gregory W
Abstract excerpt
Recent technical and methodological advances have greatly enhanced genome-wide association studies (GWAS). The advent of low-cost, whole-genome sequencing facilitates high-resolution variant identification, and the development of linear mixed models (LMM) allows improved identification of putatively causal variants. While essential for correcting false positive associations due to sample relatedness and...
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