Article

A time-to-event heritability framework for inferring the genetic architecture of longitudinal traits

2026-02-22

Abstract excerpt

Biobanks with longitudinal measurements have advanced our understanding of time-to-event (TTE) traits including age-of-onset and disease progression. However, limited work has characterized the heritability of TTE traits, a key parameter for comparisons of total association and predictive power. Here, we present COXMM, a Cox proportional hazard mixed model for estimating TTE heritability. Simulations show our mode...

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Literature Corpus work: 4863beee-387e-513c-8a56-93e6e0f49f85
DOI: 10.64898/2026.02.16.26346285

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