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Article

Fast Algorithms for Conducting Large-Scale GWAS of Age-at-Onset Traits Using Cox Mixed-Effects Models.

Genetics - 1 May 2020

He Liang, Kulminski Alexander M

Abstract excerpt

Age-at-onset is one of the critical traits in cohort studies of age-related diseases. Large-scale genome-wide association studies (GWAS) of age-at-onset traits can provide more insights into genetic effects on disease progression and transitions between stages. Moreover, proportional hazards (or Cox) regression models can achieve higher statistical power in a cohort study than a case-control trait using logistic...

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Identifiers

PMID: 32132097
DOI: 10.1534/genetics.119.302940
PMCID: PMC7198273

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