Article

Evaluating the Potential of Younger Cases and Older Controls Cohorts to Improve Discovery Power in Genome-wide Association Studies of Late-onset Diseases

2019-07-05

Abstract excerpt

For more than a decade, genome-wide association studies have been making steady progress in discovering the causal gene variants that contribute to late-onset human diseases. Polygenic late-onset diseases in an aging population display the risk allele frequency decrease at older ages, caused by individuals with higher polygenic risk scores becoming ill proportionately earlier and bringing about a change in the dis...

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Identifiers and source

Literature Corpus work: 743b4de1-954c-5ff6-8857-659caa9d4c4e
DOI: 10.1101/693622

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