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Article

Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels.

eLife - 1 Jun 2022

Edmond Michaela A, Hinojo-Perez Andy, Wu Xiaoan, Perez Rodriguez Marta E, Barro-Soria Rene

Abstract excerpt

Neuronal KCNQ channels mediate the M-current, a key regulator of membrane excitability in the central and peripheral nervous systems. Mutations in KCNQ2 channels cause severe neurodevelopmental disorders, including epileptic encephalopathies. However, the impact that different mutations have on channel function remains poorly defined, largely because of our limited understanding of the voltage-sensing mechanisms...

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Identifiers

PMID: 35642783
DOI: 10.7554/eLife.77030
PMCID: PMC9197397

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