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Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal.

Heart rhythm - 1 Aug 2011

Fougere Robert R, Es-Salah-Lamoureux Zeineb, Rezazadeh Saman, Eldstrom Jodene, Fedida David

Abstract excerpt

BACKGROUND: The R582C mutation is one of many Long-QT Syndrome type 2 (LQT2)-causing mutations localized to the human ether-a-go-go related gene (hERG) channel's S5-P linker subdomain, yet its specific mechanism of dysfunction has not been examined. OBJECTIVE: This study sought to characterize the biophysical properties of the congenital LQT2-causing mutation, R582C, and utilize this mutation to provide the first...

Topics

DNA, Complementary
ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels
Fluorometry
HEK293 Cells
Humans
Long QT Syndrome
Mutation
Patch-Clamp Techniques
Phenethylamines
Potassium Channel Blockers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Transport

Sulfonamides

Transfection

Source

Identifiers

PMID: 21376840
DOI: 10.1016/j.hrthm.2011.02.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Functional characterization of the LQT2-causing mutation R582C and the associated voltage-dependent fluorescence signal.PMID 21376840Read ↗

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