Article

Two-step voltage-sensor activation of the human K <sub>V</sub> 7.4 channel and effect of a deafness-associated mutation

2025-02-05

Abstract excerpt

Voltage-gated, potassium-selective K V 7.4 channels are expressed in the inner ear and are crucial for hair-cell function and survival. Loss-of-function variants of KCNQ4 , the gene encoding K V 7.4-channel subunits, cause non-syndromic progressive hearing loss (DFNA2). K V 7.4 opening requires a voltage-dependent conformational change (activation) of the charged voltage-sensor domains (VSDs), and its transduc...

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Literature Corpus work: 268dbffa-5012-5f76-93a8-e2d1efe0942d
DOI: 10.1101/2025.02.04.636443

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