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RasV12 Expression in Microglia Promotes Retinal Inflammatory Circuits and Impairment of Photoreceptor

2020-05-27

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Microglial activation is commonly observed in neurodegenerative diseases. However, its role in the complex inflammatory network remains unclear. In this study, we generated a microglial activation mouse model by inducing the expression of a constitutively active form of Ras in microglia.<bold>Methods </bold>The double transgenic lines <italic>CAG-LSL-RasV12-IRES-...

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Literature Corpus work
9d35ac27-b765-5fbe-a4e1-56fa838359f6
DOI
10.21203/rs.3.rs-29744/v1
Open publication

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RasV12 Expression in Microglia Promotes Retinal Inflammatory Circuits and Impairment of PhotoreceptorDOI 10.21203/rs.3.rs-29744/v1
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