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Article

Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosa

29 Apr 2019

Abstract excerpt

Retinitis pigmentosa (RP) is a disease that initially presents as night blindness due to genetic deficits in the rod photoreceptors of the retina. Rods then die, causing dysfunction and death of cone photoreceptors, the cell type that mediates high acuity and color vision, ultimately leading to blindness. We investigated immune responses in mouse models of RP and found evidence of microglia activation throughout...

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Share to Neuroinflammation and Neurodegeneration Mechanisms
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PMID: 31036641
DOI: 10.1073/pnas.1901787116

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