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E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration

6 Feb 2024

Abstract excerpt

Abstract Activated microglia have been implicated in the pathogenesis of age-related macular degeneration (AMD), diabetic retinopathy, and other neurodegenerative and neuroinflammatory disorders, but our understanding of the mechanisms behind their activation is in infant stages. With the goal of identifying novel genes associated with microglial activation in the retina, we applied a semiquantitative fundus spot...

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Share to Neuroinflammation and Neurodegeneration Mechanisms
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PMID: 38321224
DOI: 10.1038/s41598-024-53731-8

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