High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing.

doi:10.1038/s41467-026-76020-6

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Article

High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing.

Nature communications - 27 Jul 2026

Hong Mengjia, Luan Changming, Yuan Meng, Huang Hao, Guo Xinyuan, Meng Dihao, Huang Molin, Xu Ye, Zhao Shanghui, Chen Ke, Chen Jiao, Li Dali, Chen Liang

Abstract excerpt

Base editors hold great promise in endogenous mutagenesis for genetic screening. However, the development of base editors that induce saturated multi-base conversions with diverse mutation spectrum is challenging. Here, we develop triple base editors (smACGs) that simultaneously mutagenize adenine, cytosine, and guanine within the same allele. Through screening and embedding engineered deaminase and alkyladenine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42649208
DOI: 10.1038/s41467-026-76020-6
PMCID: PMC13518996

Genes

HBEGF
SF3B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.