Article
Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.
Genome biology - 18 Apr 2023
Li Shuang, Schmid Katharina T, de Vries Dylan H, Korshevniuk Maryna, Losert Corinna, Oelen Roy, van Blokland Irene V, Groot Hilde E, Swertz Morris A, van der Harst Pim, Westra Harm-Jan, van der Wijst Monique G P, Heinig Matthias, Franke Lude
Abstract excerpt
BACKGROUND: Expression quantitative trait loci (eQTL) studies show how genetic variants affect downstream gene expression. Single-cell data allows reconstruction of personalized co-expression networks and therefore the identification of SNPs altering co-expression patterns (co-expression QTLs, co-eQTLs) and the affected upstream regulatory processes using a limited number of individuals. RESULTS: We conduct a...
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