Article

Amphiregulin promotes remyelination by reprogramming microglia and priming OPC differentiation

2026-06-04

Abstract excerpt

<title>Abstract</title> <p>Remyelination failure is a central obstacle in demyelinating diseases, yet the endogenous signals coordinating CNS repair remain poorly defined. Here we identify amphiregulin (AREG), an EGFR ligand produced by regulatory immune cells during peripheral tissue repair, as a coordinator of central nervous system remyelination. Systemic AAV delivery drives astrocytic AREG expression in the m...

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Identifiers and source

Literature Corpus work: 8fde4467-15ff-5906-8380-030acd736da8
DOI: 10.21203/rs.3.rs-9657185/v1

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