Article

Aberrant oxidative metabolism selects for <i>TET2</i> -deficient hematopoietic stem and progenitor cells

2026-03-02

Abstract excerpt

The mechanism(s) driving selective expansion of mutant hematopoietic stem and progenitor cells (HSPC) in clonal hematopoiesis (CH) are incompletely understood. Here, we address the role of metabolism in selection for HSPC with loss of function mutations in TET2 . Loss of Tet2 in murine HSPC triggers overexpression of glycolysis and oxidative phosphorylation genes and increased oxidative metabolism via an enlarge...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8fdde9d2-8a97-51c0-92c9-ccff04158c70
DOI: 10.64898/2026.02.28.707294

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aberrant oxidative metabolism selects for <i>TET2</i> -deficient hematopoietic stem and progenitor cellsDOI 10.64898/2026.02.28.707294Read

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.Semantic proximity Read

Oxidative stress and hypoxia in normal and leukemic stem cells.Semantic proximity Read

Metabolic Profiles of Cancer Stem Cells and Normal Stem Cells and Their Therapeutic SignificanceSemantic proximity Read

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemiaSemantic proximity Read

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional declineSemantic proximity Read

From the (Epi)Genome to Metabolism and Vice Versa; Examples from Hematologic Malignancy.Semantic proximity Read

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.Semantic proximity Read

Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in LeukemogenesisSemantic proximity Read

TET2 mutation as prototypic clonal hematopoiesis lesion.Semantic proximity Read

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.Semantic proximity Read

Proteomics reveals dynamic metabolic changes in human hematopoietic stem progenitor cells from fetal to adulthoodSemantic proximity Read

The Interactome between Metabolism and Gene Mutations in Myeloid Malignancies.Semantic proximity Read