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Article

Oxidative stress and hypoxia in normal and leukemic stem cells.

Experimental hematology - 1 Jul 2016

Testa Ugo, Labbaye Catherine, Castelli Germana, Pelosi Elvira

Abstract excerpt

The main hematopoietic stem cell (HSC) functions, self-renewal and differentiation, are finely regulated by both intrinsic mechanisms such as transcriptional and epigenetic regulators and extrinsic signals originating in the bone marrow microenvironment (HSC niche) or in the body (humoral mediators). The interaction between regulatory signals and cellular metabolism is an emerging area. Several metabolic pathways...

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Source

Identifiers

PMID: 27179622
DOI: 10.1016/j.exphem.2016.04.012

Genes

IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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