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Article

The Interactome between Metabolism and Gene Mutations in Myeloid Malignancies.

International journal of molecular sciences - 19 Mar 2021

Gurnari Carmelo, Pagliuca Simona, Visconte Valeria

Abstract excerpt

The study of metabolic deregulation in myeloid malignancies has led to the investigation of metabolic-targeted therapies considering that cells undergoing leukemic transformation have excessive energy demands for growth and proliferation. However, the most difficult challenge in agents targeting metabolism is to determine a window of therapeutic opportunities between normal and neoplastic cells, considering that...

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Identifiers

PMID: 33808599
DOI: 10.3390/ijms22063135
PMCID: PMC8003366

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