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Article

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

25 Sept 2018

Abstract excerpt

Diminishing potential to replace damaged tissues is a hallmark for ageing of somatic stem cells, but the mechanisms remain elusive. Here, we present proteome-wide atlases of age-associated alterations in human haematopoietic stem and progenitor cells (HPCs) and five other cell populations that constitute the bone marrow niche. For each, the abundance of a large fraction of the ~12,000 proteins identified is...

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PMID: 30275468
DOI: 10.1038/s41467-018-06353-4

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