Article

Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis

2024-09-27

Abstract excerpt

<h4>ABSTRACT</h4> The role of somatic mitochondrial DNA (mtDNA) mutations in leukemogenesis remains poorly characterized. To determine the impact of somatic mtDNA mutations on the process, we assessed the leukemogenic potential of hematopoietic progenitor cells (HPCs) from mtDNA mutator mice (Polg D257A) with or without NMyc overexpression. We observed a higher incidence of spontaneous leukemogenesis in recipient...

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Literature Corpus work: 949816f2-4242-5035-8911-f9dff8215278
DOI: 10.1101/2024.09.25.615001

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