Article

Nuclear BIN1 isoforms regulate c-Myc-mediated cell cycle control in oligodendrocytes

2025-10-01

Abstract excerpt

Bridging integrator 1 (BIN1) is a nucleocytoplasmic protein that inhibits c-Myc and acts as a tumour suppressor. BIN1 is ubiquitously expressed, but it is most abundant in skeletal myocytes and brain oligodendrocytes (OLs). BIN1 expression in the OL lineage is of particular interest, as the loss of myelin integrity is highly correlated with the progress of sporadic AD. More importantly, GWAS studies have identifie...

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Literature Corpus work: ac0c2b5a-0d9f-5f95-87d9-d8a9ef5f50a4
DOI: 10.1101/2025.09.30.676706

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