Article

Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation

2020-10-19

Abstract excerpt

The principal hallmark of Parkinson’s disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased homeostatic support and deficient neuroprotection. In this study, we generated iPSC-derived astrocytes from PD patients with LRRK2(G2019S) mutation and healthy donors of the similar age. In cell...

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Literature Corpus work: 8fc06215-b3f5-51ab-84de-8ebf5ab2c6ef
DOI: 10.21203/rs.3.rs-92523/v1

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