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Article

Metabolic alterations in Parkinson's disease astrocytes.

Scientific reports - 2 Sept 2020

Sonninen Tuuli-Maria, Hämäläinen Riikka H, Koskuvi Marja, Oksanen Minna, Shakirzyanova Anastasia, Wojciechowski Sara, Puttonen Katja, Naumenko Nikolay, Goldsteins Gundars, Laham-Karam Nihay, Lehtonen Marko, Tavi Pasi, Koistinaho Jari, Lehtonen Šárka

Abstract excerpt

In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta is associated with Lewy bodies arising from the accumulation of alpha-synuclein protein which leads ultimately to movement impairment. While PD has been considered a disease of the DA neurons, a glial contribution, in particular that of astrocytes, in PD pathogenesis is starting to be uncovered. Here, we...

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Source

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Identifiers

PMID: 32879386
DOI: 10.1038/s41598-020-71329-8
PMCID: PMC7468111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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