Article

Loss of the Parkinson’s disease-associated protein DJ-1 impacts dopamine metabolism in astrocytes

2025-11-03

Abstract excerpt

The selective loss of dopaminergic neurons in the substantia nigra is a hallmark of Parkinson’s disease (PD), yet the contribution of glial cells to this vulnerability is not fully understood. Studies in rodent models suggest that astrocytes can take up and metabolize dopamine (DA), potentially protecting neurons by detoxifying reactive DA metabolites via glutathione S-transferase mu 2 (GSTM2) release. However, th...

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Literature Corpus work: 37d4437f-a699-5e5e-877e-c749dcdc88b8
DOI: 10.1101/2025.11.02.685006

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