Article
The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson's disease.
eLife - 30 Sept 2021
de Rus Jacquet Aurelie, Tancredi Jenna L, Lemire Andrew L, DeSantis Michael C, Li Wei-Ping, O'Shea Erin K
Abstract excerpt
Astrocytes are essential cells of the central nervous system, characterized by dynamic relationships with neurons that range from functional metabolic interactions and regulation of neuronal firing activities, to the release of neurotrophic and neuroprotective factors. In Parkinson's disease (PD), dopaminergic neurons are progressively lost during the course of the disease, but the effects of PD on astrocytes and...
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