Article

Mitochondrial Metabolism and Calcium Handling in Parkinson's Disease hiPSC-derived Astrocytes

2026-08-13

Abstract excerpt

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, and mutations in the LRRK2 and PRKN genes are among the most common familial causes of the disease. In neurodegenerative diseases such as PD, disturbances in Ca 2+ ; homeostasis and cellular bioenergetics impair the function of neurons and glial cells, contributing to disease progression. These changes are not limited to neur...

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Literature Corpus work: 83997149-2215-5e7b-a253-0e29ed02d1f4
DOI: 10.64898/2026.08.07.743508

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