Article

Pharmacogenetic variants associated with off-target adverse drug reactions are mostly predicted to be benign

2019-09-23

Abstract excerpt

Tools that predict the functional importance of genetic variation almost always rely on sequence conservation across deep evolutionary divergences as a primary discriminator. However, sequence conservation information is misleading when predicting the functional importance of pharmacogenetic variants related to off-target adverse drug reactions. Sequence conservation is largely maintained by evolutionary purifying...

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Literature Corpus work: 8fb233b2-05ed-581e-9db8-ac967c1b6540
DOI: 10.1101/780213

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