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Article

How to Consider Rare Genetic Variants in Personalized Drug Therapy.

Clinical pharmacology and therapeutics - 1 May 2018

Lauschke Volker M, Ingelman-Sundberg Magnus

Abstract excerpt

Personalized drug therapy aims to optimize the efficacy of pharmacological treatments by considering genetic, pathophysiological, dietary, and environmental factors as well as comedications and compliance. A multitude of associations between the specific genetic constitution of the patient and drug pharmacokinetics and pharmacodynamics has been identified in the last decades that encompass mainly common single...

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PMID: 29313952
DOI: 10.1002/cpt.976

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