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Article

Pharmacogenetics at Scale: An Analysis of the UK Biobank.

Clinical pharmacology and therapeutics - 1 Jun 2021

McInnes Gregory, Lavertu Adam, Sangkuhl Katrin, Klein Teri E, Whirl-Carrillo Michelle, Altman Russ B

Abstract excerpt

Pharmacogenetics (PGx) studies the influence of genetic variation on drug response. Clinically actionable associations inform guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), but the broad impact of genetic variation on entire populations is not well understood. We analyzed PGx allele and phenotype frequencies for 487,409 participants in the UK Biobank, the largest PGx study...

Topics

Databases, Factual
Gene Frequency
Genetic Variation
Haplotypes
Humans
Pharmacogenetics
Pharmacology
United Kingdom
White People

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33237584
DOI: 10.1002/cpt.2122
PMCID: PMC8144239

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