Article

Genetic variation in human drug-related genes

2017-06-07

Abstract excerpt

Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classical pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied. Based on 60,706 human exomes from the ExAC dataset, we performed an in-depth computational analysis of the prevalence of functional-variants in in 806 drug-re...

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Literature Corpus work: 3ae87e06-0a02-5675-9f18-fbb8d1c4c703
DOI: 10.1101/147108

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