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Article

Integrating rare genetic variants into pharmacogenetic drug response predictions.

Human genomics - 25 May 2018

Ingelman-Sundberg Magnus, Mkrtchian Souren, Zhou Yitian, Lauschke Volker M

Abstract excerpt

BACKGROUND: Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions. Besides common genetic polymorphisms, recent sequencing projects revealed a plethora of rare genetic variants in genes encoding proteins involved in drug metabolism, transport, and response. RESULTS: To understand the global importance of rare...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29793534
DOI: 10.1186/s40246-018-0157-3
PMCID: PMC5968569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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