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Integrating rare genetic variants into pharmacogenetic drug response predictions.

Human genomics - 25 May 2018

Ingelman-Sundberg Magnus, Mkrtchian Souren, Zhou Yitian, Lauschke Volker M

Abstract excerpt

BACKGROUND: Variability in genes implicated in drug pharmacokinetics or drug response can modulate treatment efficacy or predispose to adverse drug reactions. Besides common genetic polymorphisms, recent sequencing projects revealed a plethora of rare genetic variants in genes encoding proteins involved in drug metabolism, transport, and response. RESULTS: To understand the global importance of rare...

Topics

Biomarkers, Pharmacological
Exome
Genotype
Humans
Pharmacogenetics
Pharmacogenomic Variants
Phenotype
Polymorphism, Single Nucleotide

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29793534
DOI: 10.1186/s40246-018-0157-3
PMCID: PMC5968569

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