Article

Endogenous microRNA Triggered Enzyme-free DNA Logic Self-assembly for Amplified Bioimaging and Enhanced Gene Therapy via in Situ Generation of siRNAs

2021-08-02

Abstract excerpt

<h4>Background: </h4> Small interfering RNA (siRNA) has emerged as a kind of promising therapeutic agents for cancer therapy. However, the off-target effect and degradation are the main challenges for siRNAs delivery. Herein, an enzyme-free DNA amplification strategy initiated by a specific endogenous microRNA has been developed for in situ generation of siRNAs with enhanced gene therapy effect on cervical carcino...

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Literature Corpus work: 8f9ed4b5-6153-5230-bddb-e201ac53e0a8
DOI: 10.21203/rs.3.rs-729136/v1

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Endogenous microRNA Triggered Enzyme-free DNA Logic Self-assembly for Amplified Bioimaging and Enhanced Gene Therapy via in Situ Generation of siRNAsDOI 10.21203/rs.3.rs-729136/v1Read

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