Article

Visualizing single-base RNA mutations in living cells through DNA nanostructure-mediated amplification

2026-02-15

Abstract excerpt

Capturing RNA dynamics in living cells would provide critical insights into transcriptional control and cellular adaptation, but remains technically formidable — particularly at single-base precision. Here, we introduce a DNA tetrahedron based three-dimensional catalytic hairpin assembly (3D@CHA) nanoplatform that couples target recognition with catalytic activation in a spatially organized framework. Three cascad...

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Literature Corpus work: b64c1ff9-4359-5561-bf09-50b6cb97e266
DOI: 10.64898/2026.02.14.705875

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