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Article

Theranostic DNA nanostructure based on phenotype-specific activation of antisense oligonucleotides.

Talanta - 1 Mar 2024

Chu Lok Ting, Kwong Hoi Kwan, Cui Chenyu, Chen Ting-Hsuan

Abstract excerpt

Antisense oligonucleotide (ASO) is a powerful agent for gene therapy, designed to form complementary pairs with specific mRNA to inhibit gene expression. However, low specificity limits its potential. To overcome this challenge, we developed a Y-shape DNA nanostructure that enhances the specificity in ASO-based treatment by introducing a detection trigger. The design incorporates the phenotype-specific miR21...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37979506
DOI: 10.1016/j.talanta.2023.125399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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