Article

NIR Light-Controlled DNA Nanodevice for Amplified mRNA Imaging and Precise Gene Therapy

2023-05-31

Abstract excerpt

<title>Abstract</title> <p>Accurately delivering antisense oligonucleotides (ASOs) to tumor cells for gene therapy poses a significant challenge. To address this issue, we develop a NIR light-activable DNA nanodevice to target survivin mRNA and simultaneously release ASOs in tumor cells, which allows high-precision spatiotemporal imaging with high sensitivity and efficient gene therapy. The concept is based on up...

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Literature Corpus work: 5a144cd5-fbf2-5e20-86d8-7b4accf3751b
DOI: 10.21203/rs.3.rs-2931628/v1

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