Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression <i>in vitro</i> and <i>in vivo</i>

Abstract excerpt

RNA-based agents such as siRNA, miRNA, and mRNA can selectively manipulate gene expression/proteins and have the potential to revolutionize the current therapeutic strategies for various diseases, including cancer. To address the poor stability and inherent limitations of RNA agents, nanoparticle (NP) platforms have been developed to deliver functional mRNA or siRNA inside the cells. Recent studies have focused on...

Topics

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• CAR-T cell therapy research
• Gene Expression Regulation, Neoplastic
• Gene Silencing
• Nanoparticles
• Neoplasms
• Polymorphism, Single Nucleotide
• RNA, Small Interfering
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

1478ad7a-801c-5778-903e-370cfc599b91

DOI

10.1101/2024.06.22.600196