Article

Constitutional activation of BMP4 and WNT signalling in hESC results in impaired mesendoderm differentiation

2020-06-05

Abstract excerpt

We identified a human embryonic stem cell subline that fails to respond to the differentiation cues needed to obtain mesendoderm derivatives, differentiating into trophoblast-like cells instead. RNA-sequencing analysis showed that the subline has hyperactivation of the WNT and BMP4 signalling. Modulation of these pathways with small molecules confirmed them as the cause of the differentiation impairment. While act...

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Literature Corpus work: 8f94f33b-7f0a-5aa6-aad8-83af0e75f4dd
DOI: 10.1101/2020.06.04.133496

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