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Article

Endogenous WNT signals mediate BMP-induced and spontaneous differentiation of epiblast stem cells and human embryonic stem cells.

Stem cell reports - 13 Jan 2015

Kurek Dorota, Neagu Alex, Tastemel Melodi, Tüysüz Nesrin, Lehmann Johannes, van de Werken Harmen J G, Philipsen Sjaak, van der Linden Reinier, Maas Alex, van IJcken Wilfred F J, Drukker Micha, Ten Berge Derk

Abstract excerpt

Therapeutic application of human embryonic stem cells (hESCs) requires precise control over their differentiation. However, spontaneous differentiation is prevalent, and growth factors induce multiple cell types; e.g., the mesoderm inducer BMP4 generates both mesoderm and trophoblast. Here we identify endogenous WNT signals as BMP targets that are required and sufficient for mesoderm induction, while trophoblast...

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Identifiers

PMID: 25544567
DOI: 10.1016/j.stemcr.2014.11.007
PMCID: PMC4297870

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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