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Human naive epiblast cells possess unrestricted lineage potential

7 Apr 2021

Abstract excerpt

Classic embryological experiments have established that the early mouse embryo develops via sequential lineage bifurcations. The first segregated lineage is the trophectoderm, essential for blastocyst formation. Mouse naive epiblast and derivative embryonic stem cells are restricted accordingly from producing trophectoderm. Here we show, in contrast, that human naive embryonic stem cells readily make blastocyst...

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PMID: 33831366
DOI: 10.1016/j.stem.2021.02.025

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